Few studies on vaccinations are properly controlled for side effects or efficacy. And they mostly just compare their product to an older one and to vaccines for different diseases. Additionally, they are shielded from liability in the US.
Pharmaceutical companies have an atrocious record as far as product safety goes. I understand the theory of vaccines is sound but that hardly means anything when dealing with big pharma.
The studies I've worked on looking at side effects and efficacy of vaccines, and that several vaccines have been taken off the market because of product safety concerns will be surprised to hear this.
Two rotavirus vaccines were suspected of causing a rare but serious side effect (that they actually caused it at higher rates is somewhat less clear). They were immediately pulled off the market, and replaced with a vaccine that doesn't cause said side effect - which has been vigilantly monitored with post-market studies ever since.
You'll find them relatively easily for novel vaccines. In another post I mention unethical studies. Asking for new RCTs for existing vaccines used to prevent childhood disease is absurdly unethical, and would never pass muster at any self-respecting institutional review board. The best you'll get is comparisons between new formulations and existing vaccines, ala https://clinicaltrials.gov/ct2/show/NCT00861744 because there's no reason to put a swath of children at risk of preventable childhood diseases when we have working vaccines with very little evidence of serious side effects.
I think doctors will need to get over these ethical issues before immunization could ever be compulsory. It's just as unethical to force a treatment that's not been properly tested on a population, as it is to not expose them to that treatment.
Vaccines are not like other medications. With many medications, there is a benefit only to one person. With vaccines, there are benefits to an entire society (especially those who are not healthy enough to take vaccines themselves).
We know that the highly recommended, widely used vaccines are safe. But even if they weren't, there should still be a higher tolerance of risk because the danger that they prevent is certain and extreme.
Pharmaceutical companies have an atrocious record as far as product safety goes. I understand the theory of vaccines is sound but that hardly means anything when dealing with big pharma.