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LDL levels is too complex to be used as the litmus test it has become.

This might dependent on how much you care about false positives and pushing wrong advice to people, but the difference in levels in non Caucasian ethnies in particular is kind of ignored in most directives.

When looking deeper into it, it's a lot more complex than a simple "higher than X is market for Y". For instance:

https://www.ahajournals.org/doi/10.1161/01.atv.19.9.2234

> In conclusion, we have found an ethnic difference in the LDL size distribution, with African Americans having the highest LDL size (“less atherogenic”) and Hispanics having the lowest LDL size; these ethnic differences in LDL size, however, appear to be primarily due to differences in triglyceride and HDL cholesterol among the ethnic groups. Similar variables (triglyceride, HDL cholesterol, insulin resistance, etc) appear to be related to LDL size in these ethnic groups. Last, ethnic differences in LDL size are not consistent with previously reported differences in their risk of CVD or atherosclerosis; in fact, the ethnic differences in LDL size may be opposite the CVD risk differences by ethnic group.



Discordances like this between LDL-c and ApoB are one of the reasons many lipidologists are pushing for LDL-c measurement to be replaced with ApoB.




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