No ECC is the biggest trade off for me, but the C236 express chipset has very little choice for CPUs, they are all 4 core 8 thread. Ive got multiple x99 platform systems and for a long time they were the king of cost efficiency, but lately the ryzen laptop chips are becoming too good to pass up, even without ECC. Eg Ryzen 5825u minis
Most computers don't have ECC. So it might be essential in theory but in practice things work fine without (for standard personal, even work, use cases).