The Total Perspective Vortex in Hitchhiker's notably didn't do anything bad when it was turned on, and so is good evidence that inventing the torment nexus is fine.
It didn't do anything bad to Zaphod Beeblebrox, in a pocket universe created especially for him (therefore ensuring that he was the most important thing in it, and thereby securing his immunity from the mind-scrambling effects of fully comprehending the infinite smallness of one's place in the real universe).
