If you would give a talk about this, I would watch it - despite being out of the graphics for almost 10 years now. Really want to hear from the trenches about the workflows, benefits and challenges you have.
Here is a test I did the other day of rough sketch (hand drawn) -> clean line work (AI) -> coloured (AI). This workflow gives 100% control over the output because you can easily adjust the linework in the intermediary step.
