Adobe's Acrobat editor is painful and barely usable even for ordinary prose. There's no way I'd try it for math. To be fair though, it does not seem intended for heavy-duty editing - it's more for: someone gave me this PDF, I don't have the source document, I need to make some little tweaks directly to the PDF.
Yeah Acrobat and ABBYY editors are really only useful as a last resort when you don't have time to recreate someone's PDF but you really need a couple words changed.
But they are life-savers when that's your situation.