I don't know about GWT, but in my experience closure compiler does not produce different output for different browsers (though it does strip dead code).
It has the ability, but doesn't not part of the default IIRC unlike GWT which is built around permutations. GMail I think varies permutations. However, there are sound reasons for wanting to do so besides differing DOM capabilities, namely, that different JS VMs have different performance characteristics and what may be an optimal pattern for one, isn't for another.
