"exactly where the supply comes from is probably a fascinating story never to be fully told."
Where it's made is one matter but I'd imagine its only significant precursor would be ergotamine tartrate (a la Hoffman), as ergotamine is a commonly available drug for migraine (although somewhat less so than some years back, as it's been largely superceded by sumatriptan).
The next alternative I'd imagine would be to get 'raw' ergot and process it: https://en.m.wikipedia.org/wiki/Ergot although I'd guess that gathering and refining the fungus would be no mean feat for any backyard manufacturer.
It's hard to imagine there being any other major human-manufactured precursor due to the complexity of the molecule. Moreover, refined ergotamine for medical use is a mixture of various ergot
alkaloids. Presumably, this would complicate the synthesis but I've never bothered to think about how it would or to what extent.
Where it's made is one matter but I'd imagine its only significant precursor would be ergotamine tartrate (a la Hoffman), as ergotamine is a commonly available drug for migraine (although somewhat less so than some years back, as it's been largely superceded by sumatriptan).
The next alternative I'd imagine would be to get 'raw' ergot and process it: https://en.m.wikipedia.org/wiki/Ergot although I'd guess that gathering and refining the fungus would be no mean feat for any backyard manufacturer.
It's hard to imagine there being any other major human-manufactured precursor due to the complexity of the molecule. Moreover, refined ergotamine for medical use is a mixture of various ergot alkaloids. Presumably, this would complicate the synthesis but I've never bothered to think about how it would or to what extent.