There certainly are many cultures (e.g. Eastern or Northern Europe) where the expected response to "How are you doing?" would be either a truthful description of the important problems in their life that they are currently concerned about or becoming creeped out because you're asking a rather private question and you aren't close enough so that it would be reasonable for them to tell you how they're actually doing, nor it would be reasonable for them to lie with "I'm great!" - i.e. where the question isn't appropriate to be used randomly by near-strangers.