The headline really, really annoys me. It makes it sound causal, amyloid-B removal causes reversing symptoms of alzheimer's. Thus supporting and even making seem certain the still somehow overwhelmingly popular (not to sound like conspiracy anti-pharma guy(1)) amyloid theory of alzheimers.
All this shows is that one of the effects of the treatment is clearing aggregates, IN MICE. That's it, nothing more.
We don't know for sure the causal mechanism. There was/is a fanatical well-funded machine behind the amyloid hypothesis; that doesn't make it correct. There is much reason to doubt it or at least downgrade it to a contributing but not sole causal mechanism.
(1) it is absolutely mind-boggling to me that the amyloid clearing drugs like Aduhelm got FDA approval while so many much more proven treatments for other diseases sit waiting.
All this shows is that one of the effects of the treatment is clearing aggregates, IN MICE. That's it, nothing more.
We don't know for sure the causal mechanism. There was/is a fanatical well-funded machine behind the amyloid hypothesis; that doesn't make it correct. There is much reason to doubt it or at least downgrade it to a contributing but not sole causal mechanism.
(1) it is absolutely mind-boggling to me that the amyloid clearing drugs like Aduhelm got FDA approval while so many much more proven treatments for other diseases sit waiting.