A: What behaviors or environments lead to adult immune systems calibrated to minimize autoimmune dysfunctions.
B: Comparing populations that already/ haven't developed inherited countermeasures against certain diseases.
C: (In some cases) Specific pathogens where it is less-damaging to encounter them at different phases of life.
In particular, I'd point out that sometimes a population strong against a particular disease does not necessarily have "better" immune systems... Sometimes it's literally survivorship bias, where all of the vulnerable individuals they used to have already died in tragic ways.
A: What behaviors or environments lead to adult immune systems calibrated to minimize autoimmune dysfunctions.
B: Comparing populations that already/ haven't developed inherited countermeasures against certain diseases.
C: (In some cases) Specific pathogens where it is less-damaging to encounter them at different phases of life.
In particular, I'd point out that sometimes a population strong against a particular disease does not necessarily have "better" immune systems... Sometimes it's literally survivorship bias, where all of the vulnerable individuals they used to have already died in tragic ways.